RRPV BoNT-NMJ

Frist:11 May 2026, 13:00 GMT-4

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WASHINGTON, Vereinigte Staaten

Art: Sources Sought
Verfahren: Sources Sought
Referenznummer: 78111dd8f1d54f3783a4e98804f52351
NAICS: 541714

Botulinum neurotoxins (BoNT/A�G) inhibit acetylcholine release at the neuromuscular junction through cleavage of SNARE proteins (e.g., SNAP-25, VAMP, syntaxin). Currently, BoNT characterization, including toxin potency a…

nd neutralization by medical countermeasures, is measured using mouse-based bioassays, primarily the Mouse Potency Assay (MPA) and Mouse Neutralization Assay (MNA), respectively. There is increasing scientific, ethical, and regulatory interest in transitioning to human-relevant in vitro systems that

can provide mechanistic insight while reducing reliance on animal testing. NMJ micro-physiological systems may provide a biologically relevant platform capable of measuring BoNT potency and evaluating countermeasure efficacy. BARDA is inte

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