Procurement of spectrofluorometer

ly healthy. This extreme segregation of phenotypes warrants a deeper understanding of the molecular impact of CaM mutations, to understand why some variants result in a pathogenic phenotype and other variants do not. Thus, the aim of this project is to determine which human Calmodulin mutations impa

ir the ability to bind Ca2+-ions and decode intracellular Ca2+-signals to target proteins. We wish to upgrade our experimental platform with a new spectrofluorometer for measuring the Ca2+-affinity of CaM variants. Calcium binding to the Ca