We require an instrument that can: * sequence regions of the genome that cannot be adequately covered using short-read sequencing technologies; * generate long reads of up to 25,999 bases with an error rate of less than …
1% for individual molecules and an average error rate of less than 0.1% across the entire dataset; * provide direct information on DNA methylation without the need for bisulfite conversion or other enzymatic manipulations. These requirements are essential for whole human genome sequencing with a dat
a quality that enables reliable detection og single-base variants, structural variants, and difficult-to-sequence genomic regions, such as those containing pseudogenes or repetitive sequences, while simultaneously providing haplotype phasin