Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Innovative Solutions Opening (ISO)

CIRCLE) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from this announcement. CIRCLE seeks to create a critical illness Control Point Validation Engine that leads to improvements in intensive care unit (ICU) health outcomes, coupled to reduced stay time and

associated costs, by assessing, predicting, and treating immuno-inflammatory dysregulation before it causes organ failure. Interested parties are invited to review the attached CIRCLE ISO ARPA-H-SOL-26-139 and its Attachments A � F. Propose