Cap-dependent endonuclease inhibitors (CENis) - NHRC

Deadline:25 May 2026, 17:00 GMT-4

Tender information

SAM.gov

NORFOLK, United States

Type: Combined Synopsis/Solicitation
Procedure: Combined Synopsis/Solicitation
Ref. number: 7ca6661dd9ec4edb86296ad3bc28a805
NAICS: 541715

The preclinical development of Cap-dependent endonuclease inhibitors (CENi), a class of small molecules, as broad-spectrum antiviral therapeutics. The scope of this project includes all activities required to select lead…

CENi candidates, including in vitro and in vivo efficacy studies and characterization and optimization of lead compounds. This includes Research Support expertise regarding the preclinical development of cap-dependent endonuclease inhibitors (CENis) with viruses that require biosafety level 4 (BSL-

4) containment to support the Naval Medical Research Command in Fort Detrick, MD. This work will be performed over a 36-month period.

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